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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: Trends Biochem Sci. 2023 May 10;48(8):713–725. doi: 10.1016/j.tibs.2023.04.004

Figure 3: Regulation of mitotic progression by dephosphorylation.

Figure 3:

(A) Scheme of relative activities of mitotic kinases and PPPs between cell cycles (adapted from Nasa and Kettenbach [83]). (B) Mechanism of regulation of PP2A-B55 holoenzyme activity by Ensa/Arpp19 during mitotic entry and exit. (C) Orderly reactivation of APC/C by Cdc20 and Cdh1 upon mitotic exit based on PP2A-B55 holoenzyme phosphorylation site preference for pT over pS. (D) Phosphorylation-dependent regulation of PPP SLiM-based substrate recruitment by PP2A-B56 and PP1 and its effects on the regulation of microtubule attachment and spindle assembly checkpoint signaling at the kinetochore.