TABLE 4.

Postrelapse survival: Prognostic factors associated with presentation of second relapse.

		Overall survival
	Patients	2‐year		5‐year
		Rate	SE	Rate	SE	p *
All with second recurrence	124	0.628	0.044	0.302	0.044
Time to second relapse after primary disease
< Median (38 months)	60	0.467	0.066	0.186	0.057	0.001
≥ Median	63	0.789	0.052	0.406	0.065
Unknown	1
Time to second relapse after first recurrence
< Median (9 months)	61	0.395	0.065	0.194	0.057	<0.001
≥ Median	62	0.854	0.045	0.407	0.065
Unknown	1
Diagnostics
Imaging	58	0.694	0.062	0.384	0.071	0.001
Signs and symptoms	31	0.478	0.091	0.102	0.056
Unknown	35
Sites of tumour/metastatic involvement at relapse diagnosis
Intrapulmonary only	61	0.695	0.060	0.386	0.067	0.005
Extrapulmonary (bone, others) only	37	0.673	0.078	0.313	0.080
Both	20	0.394	0.111	0.113	0.074
Unknown	6
Laterality of lung metastases at relapse diagnosis
Ipsilateral	38	0.594	0.081	0.316	0.080	0.128
Contralateral	13	0.839	0.104	0.490	0.148
Bilateral	21	0.747	0.098	0.201	0.100
Unknown	9
Diameter (max.) of lung metastases at relapse diagnosis
<17 mm	14	0.844	0.102	0.394	0.148	0.306
≥17 mm	17	0.706	0.111	0.235	0.114
Unknown	50
Pleural effusion at relapse diagnosis
No	35	0.677	0.080	0.334	0.091	0.572
Yes	5	0.600	0.219	0.300	0.239
Unknown	84
Pleural disruption at relapse diagnosis
No	20	0.737	0.101	0.289	0.108	0.673
Yes	7	0.429	0.187	0.286	0.171
Unknown	97

Note: All the p‐values that show a significant difference between the respective parameters are printed in bold. 

^*Log‐rank.