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. Author manuscript; available in PMC: 2024 Feb 15.
Published in final edited form as: Cancer Res. 2023 Aug 15;83(16):2790–2806. doi: 10.1158/0008-5472.CAN-22-2220

Figure 5. Rab27 knockout attenuated the inhibitory effect of TEVs on Meso-CAR T cells.

Figure 5.

A, Schema of NSG mice with 4662 tumors or RAB27A KO 4662 tumors were treated with Meso-CAR T cells and injected with 4662 cell-derived sEVs with indicated treatments. See Materials and Methods for details. B, Growth curves of tumors in mice with indicated treatment. C, Tumor weights with indicated treatment. D, Survival curves of mice with indicated treatment. E, Representative immunofluorescence images of Meso-CAR T cells in tumor tissues. Scale bar, 200 μm. F, The number of Meso-CAR T cells for each group of mice quantified from (E). G, The number of Meso-CAR T cells in tumors for each group of mice quantified from flow cytometry analysis. H, The percentage of IFN-γ+ Meso-CAR T cells quantified by flow cytometry. Data represent mean ± s.d. (n=5). Statistical analysis is performed using Welch ANOVA with Dunnett’s T3 multiple comparison tests (B) or Welch ANOVA with Dunnett’s T3 multiple comparison tests (C, F-H) or log-rank test (D).