Table 2:
Participant characteristics stratified by CLAD
| Overall | Did not develop CLAD | Developed CLAD | P value | |
|---|---|---|---|---|
|
| ||||
| No. of subjects | 231 | 118 | 113 | |
| Male, No. (%) | 127 (55.0) | 67 (56.8) | 60 (53.1) | 0.574 |
| Age, mean ± SD | 55.7 ± 12.1 | 56.2 ± 12.2 | 55.1 ± 12.0 | 0.491 |
| Age, No. (%) | ||||
| < 35 years | 20 (8.7) | 10 (8.5) | 10 (8.9) | 0.965 |
| 35–49 years | 41 (17.8) | 22 (18.6) | 19 (16.8) | |
| 50–64 years | 111 (48.1) | 55 (46.6) | 56 (49.6) | |
| ≥65 years | 59 (25.5) | 31 (26.3) | 28 (24.8) | |
| Race, No. (%) | ||||
| White | 165 (71.4) | 83 (70.3) | 82 (72.6) | 0.884 |
| Black | 19 (8.2) | 10 (8.5) | 9 (8.0) | |
| Asian | 11 (4.8) | 5 (4.2) | 6 (5.3) | |
| Hispanic | 32 (13.9) | 17 (14.4) | 15 (13.3) | |
| Other | 4 (1.7) | 3 (2.5) | 1 (0.9) | |
| Diagnosis, No. (%) | ||||
| A (e.g. Obstructive lung disease) | 37 (16.0) | 18 (15.3) | 19 (16.8) | 0.770 |
| B (e.g. Pulmonary Hypertension) | 10 (4.3) | 4 (3.4) | 6 (5.3) | |
| C (e.g. Suppurative lung disease) | 20 (8.7) | 9 (7.6) | 11 (9.7) | |
| D (e.g. Pulmonary Fibrosis) | 164 (71.0) | 87 (73.7) | 77 (68.1) | |
| BMI (kg/m2) , mean ± SD | 25.5 ± 4.4 | 25.3 ± 4.3 | 25.8 ± 4.4 | 0.406 |
| FEV1 % predicted, mean ± SD | 45.4 ± 20.5 | 44.5 ± 19.8 | 46.3 ± 21.2 | 0.485 |
| FEV1 % predicted, median (Q1, Q3) | 46.0 (28.0, 60.0) | 43.0 (29.0, 59.0) | 47.0 (27.0, 62.0) | 0.544 |
| 6 MWD (m), mean ± SD | 254.4 ± 140.8 | 249.5 ± 144.8 | 259.6 ± 136.9 | 0.589 |
| 6 MWD (m), median (Q1, Q3) | 268.2 (142.7, 366.0) | 274.5 (122.0, 366.0) | 264.2 (155.0, 363.0) | 0.672 |
| LAS at transplant, mean ± SD | 58.5 ± 21.5 | 59.0 ± 21.1 | 58.0 ± 21.8 | 0.710 |
| LAS at transplant, median (Q1, Q3) | 52.0 (39.0, 79.0) | 52.5 (40.0, 80.0) | 50.0 (39.0, 73.0) | 0.645 |
| Transplant type, No. (%) | ||||
| Bilateral | 215 (93.1) | 111 (94.1) | 104 (92.0) | 0.550 |
| Single | 13 (5.6) | 5 (4.2) | 8 (7.1) | |
| Heart/Lung | 3 (1.3) | 2 (1.7) | 1 (0.9) | |
| Inpatient at transplant, No. (%) | 76 (32.9) | 41 (34.7) | 35 (31.0) | 0.542 |
| Ventilator at transplant, No. (%) | 21 (9.1) | 9 (7.6) | 12 (10.6) | 0.429 |
| ECMO at transplant, No. (%) | 18 (7.8) | 8 (6.8) | 10 (8.9) | 0.557 |
| Pre-transplant SPPB, mean ± SD | 9.0 ± 3.1 | 9.0 ± 3.1 | 9.0 ± 3.0 | 0.894 |
| Pre-transplant SPPB, median (Q1, Q3) | 10.0 (8.0, 11.0) | 9.5 (8.0, 11.0) | 10.0 (8.0, 11.0) | 0.952 |