Table 4:

Association of transplant-related frailty and CLAD

Predictor		HR for CLAD (95% CI)	p-value
Frailty (SPPB ≤9)	Unadjusted	1.77 (1.11, 2.82)	0.017
	Adjusted for CMV status, ACR grades ≥ A2 and other covariates*	1.76 (1.05, 2.92)	0.031
	Adjusted for CMV status, ACR grades ≥ A1 and above, and other covariates*	1.76 (1.06, 2.93)	0.028
1-point worsening in SPPB	Unadjusted	1.10 (1.03, 1.17)	0.005
	Adjusted for CMV status, ACR grades ≥ A2, and other covariates*	1.10 (1.03, 1.18)	0.007
	Adjusted for CMV status, ACR grades ≥ A1 and other covariates*	1.10 (1.03, 1.17)	0.009

Short Physical Performance Battery (SPPB), range from 0 to 12 (Minimal Important Difference [MID] = 1); The association between frailty and CLAD was quantified by Cox’s proportional hazards models with SPPB as a time-dependent predictor.

^*Other covariates included pre-operative age, sex, race, diagnosis, and BMI at each study visit.