Table 1:
Key Baseline Characteristics by Treatment Group
| LGG Treated Group | Placebo Treated Group | Total | |
|---|---|---|---|
| Demographics and Drinking [Mean ± SD) | |||
| Age (yrs.) | 44.2 ± 12.0 | 45.0 ± 9.4 | 44.6 ± 10.7 |
| Sex (F=Female, n=numbers) | F=9 (37.5%) | F=11 (50%) | F=20, M=25 |
| BMI (Unit Count) |
30±7.6 |
26±5.5 | 27.7 ± 6.9 |
| AUDIT (Unit Count) | 23.18 ± 8.4 | 25.05 ± 9.7 | 24.1 ± 9.0 |
| LTDH (yrs.) | 16.7 ± 11.7 | 23 ± 13.6 | 19.6 ± 13 |
| Clinical Characteristics | |||
| Albumin (g/dL) | 2.7 ± 0.6 | 2.8 ± 0.5 | 2.7 ± 0.6 |
| Alkaline phosphatase (IU) | 196.8 ± 94.1 | 197.6 ± 100.6 | 197.2 ± 96.1 |
| ALT (IU) | 73.7 ± 47.2 | 55.4 ± 33.9 | 65.1 ± 42.1 |
| AST (IU) | 169.2 ± 89.4 | 170.5 ± 80.2 | 169.8 ± 84.3 |
| AST:ALT (Unit score) | 2.7 ± 1.5 | 3.5 ± 1.3 | 3.1 ± 1.5 |
| Bilirubin (mg/dL) | 7.2 ± 4.5 | 9.5 ± 7.7 | 8.3 ± 6.2 |
| BMI (kg/m2) | 29.6 ± 7.7 | 25.7 ± 5.5 | 27.7 ± 7.0 |
| Creatinine (mg/dL) | 0.6 ± 0.2 | 0.6 ± 0.2 | 0.6 ± 0.2 |
| CONUT Score* | 6.8 ± 3.2 | 4.9 ± 2.0 | 6.2 ± 2.9 |
| Globulin (g/dL) | 3.4 ± 1.1 | 3.7 ± 1.0 | 3.5 ± 1.1 |
| Maximum Hand Grip Score (psi) | 39.1 ± 22.9 | 35.3 ± 20.6 | 37.4 ± 21.7 |
| MELD (Unit Count) | 17.4 ± 1.8 | 16.7 ± 2.4 | 17.1 ± 2.1 |
| Total Protein (g/dL) | 6.2 ± 1.2 | 6.6 ± 1.1 | 6.4 ± 1.2 |
| Maddrey DF (Unit Count) | 21.8 ± 13.1 | 18.18 ± 10.3 | 20.1 ± 11.9 |
| Platelets (10^9) (Unit Count) | 104.9 ± 13.8 | 109.1 ± 12.5 | 106.8 ± 13.3 |
LGG - Lactobacillus GG; F – females; AUDIT - alcohol use disorder identification test (Unit – unit score); BMI - body mass index (Unit: unit score); LTDH - lifetime drinking history (Unit: years); Platelets - Unit: 10^9/L; AST:ALT ratio - aspartate aminotransferase to alanine aminotransferase ratio (Unit: unit score;, MELD - Model for end–stage liver disease score (Unit: unit score); MDF – Maddrey’s Discriminant Function (Unit: unit score).
*
CONUT Score is a measure of undernutrition degree where 0-1=normal, 2-4=light, 5-8=moderate, 9-12=severe. Data presented as Mean ± SD.