Table 10:
Supplementary fibrous and hydrogel-based nanomaterials deployed as adhesion barriers in surgery.
| Composition | Architecture | Mode of Administration | Animal Model (Evaluation Time Point) | Adhesion Score (control vs. test) (Scale) | Refs. |
|---|---|---|---|---|---|
| Squid ring teeth protein coated poly(propylene) | Mesh | Prefabricated | Rat abdominal wall resection (t=7d) | 3.1 (0 to 5) | (Leberfinger et al., 2018) |
| Poly(lactide-co-glycolide)/poly(lactide)-b-poly(ethylene glycol) fibers with layers of carboxymethyl chitosan sponge | Electrospinning and foam | Electrospinning and prefabricated | Rat abdominal wall abrasion (t=10d) | 2.4 vs. 0.23 (0 to 3) | (Xia et al., 2015) |
| Pullulan hydrogel | Hydrogel | Injection | Mouse cecal abrasion (t=14d) | 2.67 vs. 0.5 (0 to 4) | (Bang et al., 2016) |
| Carboxymethyl chitosan/carboxymethyl cellulose/collagen | Hydrogel | Prefabricated | Rat cecal abrasion (t=7d) | 3 vs. 0.5 (0 to 4) | (Cai et al., 2018) |
| Poly(N-isopropylacrylamide)grafted to chitosan and conjugated with hyaluronic acid | Hydrogel | Injection | Rat cecal abrasion (t=14d) | 3 vs. 0 (0 to 3) | (C.-H. Chen et al., 2017) |
| Pluronic F127 and oxidized hyaluronic acid | Hydrogel | Injection | Rat cecal abrasion (t=7d) | 4.5 vs. 0.33 (0 to 5) | (Z. Li et al., 2020) |
| Alginate and hyaluronic acid | Hydrogel | Prefabricated | Rat cecal and abdominal wall abrasion (t=14d) | 2.5 vs. 0.1 (0 to 3) | (Mayes et al., 2020) |
| Silicate nanoplatelets and poly(ethylene oxide) | Hydrogel | Injection | Rat abdominal wall ligation (t=14d) | 1.25 vs. 0 (0 to 3) | (Ruiz-Esparza et al., 2021) |
| Hyaluronic acid with phenolic hydroxyl moieties | Hydrogel | Injection | Mouse abdominal wall abrasion (t=7d) | 2.8 vs. 0.6 (0 to 3) | (Sakai et al., 2015) |
| Hyaluronic acid with tempo-oxidized nanocellulose/methyl cellulose/poly(ethylene glycol) | Hydrogel | Injection | Rat cecal abrasion (t=7d) | 3.5 vs. 0 (0 to 4) | (Sultana et al., 2020) |
| Hyaluronic acid with tempo-oxidized nanocellulose/methyl cellulose/poly(ethylene glycol) | Hydrogel | Injection | Rat cecal abrasion (t=7d) | 3.875 vs. 0 (0 to 4) | (Sultana et al., 2019) |
| Carboxymethyl cellulose and glycol chitosan | Hydrogel | Injection | Rat cecal abrasion (t=14d) | 4.9 vs. 1.7 (0 to 5) | (Yang et al., 2017) |
| Poly(N-acryloyl alaninamide) | Hydrogel | Injection | Rat cecal abrasion (t=14d) | 4.8 vs. 0.2 (0 to 5) | (J. Yu et al., 2021) |
| Galactose modified xyloglucan | Hydrogel | Injection | Rat cecal abrasion (t=7d) | 4.25 vs. 0.125 (0 to 5) | (E. Zhang et al., 2017) |