. Author manuscript; available in PMC: 2024 Jul 1.

Published in final edited form as: Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2023 Apr 12;15(4):e1889. doi: 10.1002/wnan.1889

Table 3:

Select fibrous and hydrogel-based nanomaterials employed as tissue adhesives in surgery.

Composition	Architecture	Mode of Administration	Ex Vivo Tissue Type Used	Adhesion Strength (kPa)	Refs.
Poly(lactide-co-caprolactone)	Fiber	Blowspinning	Pig skin	10	(Daristotle et al., 2021)
Poly(lactide-co-caprolactone)	Fiber	Blowspinning	Pig skin / pig intestine	10 / 10	(Erdi et al., 2022)
Poly(lactide-co-caprolactone)	Fiber	Blowspinning	Pig aorta	30	(Daristotle, Zaki, et al., 2020)
Poly(dopamine) nanoparticles with poly (N-isopropylacrylamide) and loaded endothelial growth factor	Hydrogel	Prefabricated	Pig skin	85	(Han et al., 2016)
Mussel adhesive protein-hyaluronic acid shell with silk fibroin core	Needle patch	Prefabricated	Pig skin / pig intestine	125 / 105	(Jeon et al., 2019)
Four armed poly(ethylene glycol)-N-Hydroxysuccinimide ester	Hydrogel (glue)	Injection	Pig skin	175	(Kelmansky et al., 2017)
Multi armed poly(caprolactone)-N-Hydroxysuccinimide ester	Hydrogel (glue)	Prefabricated	Rat skin	100	(W. Zhang et al., 2020)
Gelatin/chitosan and crosslinked poly(acrylic acid) grafted with N-hydrosuccinimide ester	Hydrogel	Prefabricated	Pig skin / pig intestine / pig aorta	120 / 100 / 100	(Yuk et al., 2019)