Table 3.

Decline in Modified Minimental Score (from year 5 to year 10) corresponding to an increase in thigh intermuscular adiposity (from year 1 to year 6), before and after adjustment for changes in other adiposity and muscle measures. All p values are <0.001.

	Model 1^	Model 1+ Change in thigh muscle strength	Model 1+ Change in visceral adiposity	Model 1+ Change in abdominal subcutaneous adiposity	Model 1+ Change in weight	Model 1+ Change in total fat mass
Mean decline in 3MS points (Standard Deviation) from year 5 to 10 corresponding to the average IMAT increase of 4.83 cm2 from year 1 to 6.
Mean 3MS (SD)	−3.637 (0.207)	−3.582 (0.267)	−3.659 (0.218)	−3.647 (0.224)	−3.635 (0.208)	−3.646 (0.209)
Coefficients from linear mixed effect models (SE) of change in IMAT * time predicting change in 3MS
Change IMAT * time	−0.028 (0.007)	−0.027 (0.008)	−0.028 (0.008)	−0.030 (0.008)	−0.027 (0.007)	−0.027 (0.007)

IMAT: thigh intermuscular adiposity

^{^}Includes the following independent variables: change in thigh intermuscular adiposity (year 1 to 6), time, interaction of IMAT change with time, change in thigh intermuscular area (year 1 to 6), and 3MS at year 1.