Table 1. Individual animal survival and clinical notes.
Allograft survival and clinical notes for individual animals throughout the experiment. TNX, TNX-1500; MMF, mycophenolate mofetil; ACR, acute cellular rejection; AMR, antibody mediated rejection; CVL, central venous line; Bx, biopsy; BW, body weight; d, post-transplant days
| Treatment Group | Animal ID | Graft Survival (days) | Clinical Outcome | Histological diagnosis | Notes |
|---|---|---|---|---|---|
| hu5c8 | MDL5X | 90 | Explanted by protocol at end of study | ACR, CAV | |
| MC710057 | 113 | Explanted due to rejection after end of study | ACR, AMR, CAV | ||
| MDM6A | 133 | Explanted due to rejection after end of study | ACR, CAV | ||
| MDP28 | 152 | Explanted due to rejection after end of study | ACR, AMR, CAV | ||
| MFA6L | 173 | Explanted due to rejection after end of study | ACR, AMR, CAV | ||
| Median | 133 | ||||
| loTNX | M7419 | 93 | Explanted due to rejection | ACR, AMR | |
| M5420 | >105 | Euthanized with beating graft | ACR | BW loss; bowel obstruction | |
| M4520 | >183 | Euthanized at end of study | ACR | ||
| M5220 | 35 | Explanted due to rejection | ACR, AMR | CVL infection, + BC | |
| Median | 99 | ||||
| loTNX+MMF | M8820 | 146 | Explanted due to rejection | ACR, AMR, CAV | |
| M8620 | 111 | Explanted due to rejection | ACR, AMR, CAV | ||
| M8720 | 58 | Explanted due to rejection | ACR, AMR, CAV | CVL infection | |
| M5020 | 66 | Explanted due to rejection | ACR, AMR, CAV | Telemetry device infection | |
| Median | 88 | ||||
| sTNX | M921 | >181 | Elective explant at end of study | No rejection at end of study | |
| M1321 | 305 | Rejection after end of study | No rejection at end of study | d180 Bx 0R | |
| M821 | 265 | Rejection after end of study | No rejection at end of study | d180 Bx 0R | |
| M1721 | 232 | Rejection after end of study | ACR 1R, capillaritis at end of study | d180 Bx 1R | |
| M421 | 116 | Explanted due to rejection | ACR, AMR, early CAV | Endocarditis; +BC | |
| Median | >265 |