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. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Hepatology. 2023 Apr 11;78(4):1209–1222. doi: 10.1097/HEP.0000000000000401

Figure 4. Suppression of THBD-PAR1 axis improves advanced NAFLD.

Figure 4.

(A) Vorapaxar or its vehicle control (saline) was administered daily by oral gavage to WD+CCl4 mice during the last 4 weeks of diet. (B and C) Liver fibrosis (Sirius Red staining and α-SMA), hepatic inflammation (F4/80 and CD163 staining) and (D-G) senescence markers (Thbd, PAR1, SAβGal and P16) were assessed by quantitative morphometry of stained liver sections or densitometry of liver immunoblots. Results shown as MEAN +/− SEM (n=10 mice/group, *p<0.05 vs CDCO (chow diet plus corn oil vehicle), #p<0.05 vs WD+CCl4 vehicle).