A, IL-1ra biomarker trajectory groups across days 1–4 (n=372). Group 1, indicated by stars, was assigned as the reference group for multivariable, ordinal logistic regression. B, IL-8 biomarker trajectory groups across days 1–4 (n=378). Group 2, indicated by stars, was assigned as the reference group. Biomarker levels were measured in natural logged values of pg/mL.