Table 2.
Multivariable analysis of association of interleukin-8 and nonpulmonary organ dysfunctions
| Day | Number of Organ Dysfunctions | Odds Ratio | 95% Confidence Interval | p value |
|---|---|---|---|---|
|
| ||||
| 1 (n=196) |
0 | Reference | ||
| 1 | 1.46 | 1.02–2.07 | 0.04 | |
| 2 | 1.78 | 1.21–2.62 | 0.004 | |
| ≥3 | 3.14 | 1.95–5.04 | <0.001 | |
|
| ||||
| 2 (n=305) |
0 | Reference | ||
| 1 | 1.34 | 1.01–1.76 | 0.04 | |
| 2 | 1.60 | 1.15–2.22 | 0.005 | |
| ≥3 | 3.37 | 2.28–4.97 | <0.001 | |
|
| ||||
| 3 (n=264) |
0 | Reference | ||
| 1 | 1.44 | 1.03–2.00 | 0.03 | |
| 2 | 2.31 | 1.56–3.44 | <0.001 | |
| ≥3 | 3.54 | 2.25–5.56 | <0.001 | |
|
| ||||
| 4 (n=115) |
0 | Reference | ||
| 1 | 2.07 | 1.21–3.53 | 0.008 | |
| 2 | 2.15 | 1.24–3.73 | 0.007 | |
| ≥3 | 3.78 | 1.97–7.27 | <0.001 | |
All models used log-transformed interleukin-8 levels and were adjusted for ethnicity/race, continuous age, acute respiratory failure due to sepsis and oxygenation index (OI) on that day. If OI was not available, oxygen saturation index (OSI) on that study day was used to estimate OI.