Table 2.
Without the DDNOS participant
| Pathway | Pathway size | Relapse IRR | EDSS | ||||
|---|---|---|---|---|---|---|---|
| NES | p-value | q-value | NES | p-value | q-value | ||
| Androgenic Steroids | 15 | 1.4 | 0.06 | 0.13 | −0.8 | 0.77 | 0.85 |
| Ceramides | 19 | 1.4 | 0.07 | 0.15 | 2.1 | 7.17E-05 | 8.96E-04 |
| Diacylglycerol | 26 | 0.8 | 0.71 | 0.81 | 1.8 | 0.004 | 0.02 |
| Endocannabinoid | 4 | 1.3 | 0.11 | 0.19 | 0.9 | 0.69 | 0.80 |
| Fatty Acid Metabolism (Acyl Choline) | 7 | −2.2 | 2.84E-04 | 0.002 | −0.9 | 0.64 | 0.78 |
| Fatty Acid Metabolism (Acyl Carnitine) | 29 | 2.1 | 4.11E-06 | 1.03E-04 | 1.7 | 0.006 | 0.02 |
| Fatty Acid, Dicarboxylate | 19 | 1.6 | 0.02 | 0.048 | −2.5 | 1.49E-06 | 7.47E-05 |
| Fatty Acid, Monohydroxy | 16 | 1.9 | 3.68E-04 | 0.003 | −0.9 | 0.57 | 0.71 |
| Long Chain Fatty Acid | 14 | 1.6 | 0.02 | 0.04 | 1.4 | 0.08 | 0.15 |
| Lysophospholipid | 29 | −1.0 | 0.37 | 0.50 | −0.6 | 0.96 | 0.96 |
| Lysoplasmalogen | 4 | −1.5 | 0.10 | 0.18 | −1.3 | 0.15 | 0.23 |
| Medium Chain Fatty Acid | 7 | 1.4 | 0.08 | 0.15 | −0.6 | 0.92 | 0.94 |
| Monoacylglycerol | 9 | −1.6 | 0.05 | 0.12 | 1.8 | 0.004 | 0.02 |
| Phosphatidylcholine (PC) | 18 | −1.8 | 0.01 | 0.03 | −0.8 | 0.78 | 0.85 |
| Phosphatidylethanolamine (PE) | 11 | −2.3 | 2.12E-04 | 0.002 | −2.1 | 6.68E-04 | 0.004 |
| Phosphatidylinositol (PI) | 6 | −1.5 | 0.07 | 0.15 | −1.2 | 0.25 | 0.37 |
| Phospholipid Metabolism | 7 | −0.8 | 0.67 | 0.80 | 0.7 | 0.80 | 0.85 |
| Plasmalogen | 11 | −2.5 | 3.49E-05 | 5.81E-04 | −2.1 | 6.92E-04 | 0.004 |
| Polyunsaturated Fatty Acid (n3 and n6) | 14 | 1.6 | 0.02 | 0.047 | 1.9 | 9.08E-04 | 0.005 |
| Pregnenolone Steroids | 5 | 1.1 | 0.36 | 0.50 | −1.4 | 0.11 | 0.19 |
| Primary Bile Acid Metabolism | 9 | −2.0 | 0.006 | 0.02 | −1.9 | 0.005 | 0.02 |
| Progestin Steroids | 5 | 0.7 | 0.88 | 0.92 | −1.7 | 0.03 | 0.07 |
| Secondary Bile Acid Metabolism | 11 | −0.9 | 0.54 | 0.71 | −1.3 | 0.13 | 0.20 |
| Sphingolipid Metabolism | 42 | 1.0 | 0.56 | 0.71 | 1.6 | 0.01 | 0.03 |
| Sterol | 7 | −1.4 | 0.13 | 0.20 | −1.1 | 0.37 | 0.50 |
Normalized enrichment scores from metabolite set enrichment analysis derived for association with relapse rate and EDSS scores. Positive values denote positive association of metabolite levels and outcomes, while negative values denote negative association.
Metabolites that are of statistical significance are bolded.