Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2024 Sep 1.

Published in final edited form as: Alzheimers Dement. 2023 May 30;19(9):4094–4109. doi: 10.1002/alz.13168

Figure 4. — This plot is based on the fold change differences in the snRNA-seq data for the genes and transcription factors identified in the bioinformatics analysis for all of the LOAD GWAS regions. The fold change is calculated as the difference between late-stage AD (LOAD) and age-matched cognitively healthy controls (74–90+years old). The plot shows the relationship between fold change (log₂ fold change (FC); horizontal axis) and FDR-adjusted statistical significance (−log₁₀ (p value); vertical axis), respectively. The horizontal line corresponds to a cut-off of FDR P value ≤ 0.1, vertical lines correspond to log₂ fold change thresholds of ± 0.2. (A) ROSMAP data analysis. Cell type abbreviations: Oli-oligodendrocytes, In-inhibitory neurons, Mic-microglia, Per-pericytes (B) Sample analysis from Morabito et al. data[40] Cell type abbreviations: INH-inhibitory neurons, EX-excitatory neurons, ASC-astrocytes, MG-microglia, PER-END-pericytes/endothelial cells, OPC-oligodendrocyte progenitor cells.

Figure 4. — This plot is based on the fold change differences in the snRNA-seq data for the genes and transcription factors identified in the bioinformatics analysis for all of the LOAD GWAS regions. The fold change is calculated as the difference between late-stage AD (LOAD) and age-matched cognitively healthy controls (74–90+years old). The plot shows the relationship between fold change (log₂ fold change (FC); horizontal axis) and FDR-adjusted statistical significance (−log₁₀ (p value); vertical axis), respectively. The horizontal line corresponds to a cut-off of FDR P value ≤ 0.1, vertical lines correspond to log₂ fold change thresholds of ± 0.2. (A) ROSMAP data analysis. Cell type abbreviations: Oli-oligodendrocytes, In-inhibitory neurons, Mic-microglia, Per-pericytes (B) Sample analysis from Morabito et al. data[40] Cell type abbreviations: INH-inhibitory neurons, EX-excitatory neurons, ASC-astrocytes, MG-microglia, PER-END-pericytes/endothelial cells, OPC-oligodendrocyte progenitor cells.