A. Three viral infections (HPV, MCV and HSV) were observed more commonly in AD participants with more severe disease. B. AD participants with greater disease severity more frequently had clinical features suggestive of a bacterial infection (folliculitis, impetigo, carbuncles/furuncles/abscesses, or cellulitis). C. Skin features (excoriation, hyperlinear palms, keratosis pilaris and ichthyosis) frequently observed in AD participants were observed more frequently in AD participants with more severe disease. D. A number of ocular (blepharitis, conjunctivitis and ectropion) and respiratory (wheezing) features were identified more frequently as a function of disease severity.