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. Author manuscript; available in PMC: 2024 Sep 21.
Published in final edited form as: Cell Chem Biol. 2023 May 12;30(9):1090–1103.e7. doi: 10.1016/j.chembiol.2023.04.007

Figure 2. Multiple structurally distinct FSP1 inhibitor scaffolds.

Figure 2.

The structures of FSEN1–19 are shown with their calculated IC50 values from end-point assays measuring inhibition of FSP1 activity in vitro (n=2 independent biological replicates) and their calculated EC50 values from lethal fraction (AUC) quantification in H460C GPX4KO cells (n=3 cell biological replicates).