Table 2:
Cardiovascular data at first visit that included a cardiac MRI
| Duchenne Muscular Dystrophy Median (IQR*) or N (%) |
|
|---|---|
| Left ventricular (LV†) ejection fraction (%) | 57 (49, 60) |
| LV end diastolic volume indexed (ml/m2) | 64 (57, 78) |
| LV end systolic volume indexed (ml/m2) | 29 (23, 37) |
| LV cardiac output (ml/min) | 4.8 (3.8, 5.6) |
| LV cardiac index (ml/min/m2) | 3.5 (2.9, 4.1) |
|
| |
| Circumferential strain (Ecc‡) at base | −14.3 (−16.1, −12.6) |
| Ecc at mid-LV | −15.6 (−17.6, −13.1) |
| Global Ecc | −15.6 (−17.3, −13.3) |
|
| |
| Late gadolinium enhancement (LGE§) present | 71% (N=54) |
| Anterior Base | 14 (18%) |
| Anteroseptal Base | 9 (12%) |
| Inferoseptal Base | 10 (13%) |
| Inferior Base | 36 (46%) |
| Inferolateral Base | 44 (56%) |
| Anterolateral Base | 42 (54%) |
| Anterior Mid | 16 (21%) |
| Anteroseptal Mid | 8 (10%) |
| Inferoseptal Mid | 14 (18%) |
| Inferior Mid | 36 (46%) |
| Inferolateral Mid | 44 (56%) |
| Anterolateral Mid | 41 (53%) |
| Anterior Apex | 18 (23%) |
| Septal Apex | 18 (23%) |
| Inferior Apex | 21 (27%) |
| Lateral Apex | 25 (32%) |
| Apex | 17 (22%) |
| LGE global severity score | 2 (0, 3) |
| LGE full width half maximum (%) | 26.0 (0, 34.7) |
|
| |
| Native T1 mid (ms) | 1047 (1003, 1083) |
| T2 mid (ms) | 44.6 (42.8, 46.2) |
| Extracellular volume, mid (%) | 29.5 (25.0, 33.3) |
|
| |
| Troponin I (pg/ml) | 32.7 (32.7, 125) |
| Brain natriuretic peptide (pg/ml) | 34.3 (34.3, 34.3) |
| N-terminal pro b-type natriuretic peptide (pg/ml) | 80.1 (42.7, 169.8) |
*
IQR – interquartile range
†
LV – left ventricle
‡
Ecc – circumferential strain
§
LGE – late gadolinium enhancement