Figure 8. Global hub and spatiotemporal properties of the DMN.

(A) Functional connectivity density maps showing PCC/Precuneus are both local and global hubs in the brain. Adapted from⁸⁶. (B) Graph theoretical analysis of structural connectivity reveals high degree and betweenness centrality of the mPFC and PCC/RSC, as well as the basal forebrain and thalamus. The size of each node represents its degree, and the node color illustrates node betweenness centrality. Adapted from³. (C) The DMN is located at the apex of gradients that place it functionally and spatially distant from primary sensory and motor networks. Adapted from⁸⁷. (D) Causal network influences of the DMN on six other large-scale brain networks examined using brain-wide intracranial electrophysiological recordings. Phase transfer entropy (PTE) reveals higher net causal outflow from the DMN, than the reverse, during episodic memory formation. (E) Causal influences of the DMN on other brain networks is higher during both episodic memory encoding and recall, compared to resting state. (F) DMN displays higher net causal outflow to other brain networks (DMN→Other), than the reverse (Other→DMN). Adapted from²⁴.