Table 3:

Univariate and Multivariate Cox-Regression Analyses for 5-Year Mortality Following Heart Retransplantation

	Univariate Cox Analysis		Multivariate Cox Analysis
Covariate	Hazard Ratio	95% CI	Hazard Ratio	95% CI
Heart-Kidney a at eGFR < 30mL/min/1.73m2	0.34	0.21 – 0.53	0.42	0.26 – 0.67
Heart-Kidney a at eGFR 30–45mL/min/1.73m2	0.31	0.14 – 0.70	0.29	0.13 – 0.65
Heart-Kidney a at eGFR > 45mL/min/1.73m2	0.95	0.44 – 2.08	0.68	0.30 – 1.54
Ageb	1.00	0.99 – 1.01	`0.99	0.99 – 1.01
BMIc	1.04	1.02 – 1.07	1.04	1.01 – 1.06
Waitlist durationd	1.00	0.99 – 1.01	1.00	1.00 – 1.01
Inter-transplant periodb	0.95	0.94 – 0.97	0.98	0.96 – 0.99
Female sex	1.21	0.95 – 1.56	1.16	0.89 – 1.51
Recipient race
White	reference	reference	reference	reference
Black	1.30	1.01 – 1.68	1.10	0.85 – 1.43
Hispanic	1.11	0.78 – 1.56	1.03	0.74 – 1.43
Others	0.96	0.59 – 1.57	0.92	0.55 – 1.53
Status 1A or Adult Status 1, 2	1.32	1.01 – 1.72	0.61	0.39 – 0.96
Dialysis prior to transplant	1.65	1.23 – 2.21	1.80	1.34 – 2.43
Recipient diabetes	1.37	1.07 – 1.74	1.26	0.97 – 1.64
Recipient cerebrovascular disease	0.87	0.48 – 1.57	0.77	0.43 – 1.39
Recipient history of malignancy	0.84	0.56 – 1.25	0.86	0.56 – 1.31
Inotrope dependency	1.44	1.16 – 1.79	1.16	0.93 – 1.43
Medical condition
Home	reference	reference	reference	reference
Hospitalized, non-ICU	1.08	0.77 – 1.51	1.27	0.82 – 1.97
ICU	1.69	1.30 – 2.21	1.55	0.92 – 2.60
Ventricular assist device	1.44	0.93 – 2.22	0.97	0.66 – 1.43
Intra-aortic balloon pump	1.53	1.07 – 2.20	1.31	0.94 – 1.81
Functional Status
Mild limitation	reference	reference	reference	reference
Moderate limitation	1.88	1.23 – 2.86	1.83	1.19 – 2.81
Severe Limitation	2.10	1.42 – 3.12	1.40	0.89 – 2.21
Donor ageb	1.02	1.01 – 1.02	1.02	1.01 – 1.03
Donor diabetes	1.12	0.63 – 2.00	0.95	0.48 – 1.90
Donor hypertension	1.62	1.18 – 2.21	1.38	0.95 – 2.01
Sex mismatch	1.12	0.89 – 1.42	1.15	0.86 – 1.55
Size mismatch (donor/recipient PHM ratio < 0.86)	0.77	0.50 – 1.16	0.58	0.38 – 0.89
Donor inotropic support	0.92	0.75 – 1.12	0.97	0.77 – 1.21
Donor LVEF < 50%	1.11	0.56 – 2.21	0.96	0.44 – 2.11
Ischemic timee	1.12	1.01 – 1.23	1.14	1.02 – 1.27

^aComparisons made to isolated heart retransplant

^bper 1-year increase

^cper 1-unit increase;

^dper 1-day increase

^eper 1-hour increase

eGFR=estimated glomerular filtration rate; BMI=body mass index; ICU=intensive care unit; PHM=predicted heart mass; LVEF= left ventricular ejection fraction