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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: J Thorac Oncol. 2023 May 18;18(9):1222–1232. doi: 10.1016/j.jtho.2023.05.008

Figure 5. Gene signature and gene set correlates of durable benefit from ICB.

Figure 5.

A. Volcano plot of gene signatures associated with durable benefit from ICB, defined as progression-free survival of ≥ 6 months, in patients with SCLC enrolled in CheckMate 032. Positive association with durable benefit on the X axis is to the right of 0.0 (log fold-change); negative association to the left. Y axis represents negative log of adjusted p value, with a significance threshold set at 1.0. B. KEGG gene sets associated with durable benefit. Gene sets positively correlating with durable benefit are indicated by bars to the right of 0; gene sets negatively correlating are to the left. Bar length reflects strength of association.