Table 1:
Comparison of demographic, clinical, and imaging features in those with versus without malignant edema in this study cohort
| Feature | No Malignant Edema (n=220) | Malignant Edema (n=35) |
|---|---|---|
| Age, years (SD) | 69 (14) | 67 (15) |
| Sex, female | 105 (48%) | 13 (37%) |
| Race, white non-Hispanic | 154 (70%) | 24 (69%) |
| NIHSS, baseline (IQR) | 14 (9–19) | 19 (15–23) |
| Glucose, mg/dl (IQR) | 120 (109–141) | 129 (109–160) |
| Systolic blood pressure, mm Hg (SD) | 150 (24) | 156 (18) |
| ASPECTS (IQR) | 9 (8–10) | 7 (6–9) |
| LVO location, ICA or M1 | 140 (64%) | 29 (83%) |
| tPA given | 95 (43%) | 15 (43%) |
| Thrombectomy | 136 (62%) | 23 (66%) |
| Reperfusion 2b-3 | 115 (85%) | 13 (57%) |
| Hemorrhagic transformation (PH1 or PH2) | 26 (12%) | 9 (26%) |
| Baseline relative hemispheric volume (SD) | 1.007(0.02) | 1.014 (0.02) |
| Baseline hemispheric CSF ratio (SD) | 0.95 (0.13) | 0.88 (0.13) |
| Midline shift at 24-hours (IQR) | 0 (0–0) | 2.9 (0–6) |
| ΔCSF at 24-hours (%) (IQR) | 12% (5–27) | 49% (30–71) |
| Hemispheric CSF ratio at 24-hours (IQR) | 0.82 (0.68–0.91) | 0.37 (0.30–0.60) |
| Net water uptake at 24-hours (%) (IQR) | 21 (17–25) | 21 (19–25) |
Values in parenthesis represent percentages of each group (%),standard deviation (SD), or interquartile range (IQR), as indicated.
ASPECTS, Alberta Stroke Program Early CT Score; ICA, internal carotid artery; LVO, large vessel occlusion; M1, first segment of the middle cerebral artery; n, number; NIHSS, National Institutes of Health Stroke Scale, PH, parenchymal hematoma; tPA, tissue plasminogen activator; ΔCSF, change in CSF volume from baseline.