Skip to main content
. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: Exp Hematol. 2023 May 22;124:45–55.e2. doi: 10.1016/j.exphem.2023.05.004

Figure 4: Lymphoma and leukemia genes are downregulated in Tet2 KO Lin− cells.

Figure 4:

A. Expression levels of lymphoma signature genes (from GSEA) in Tet2 Mut and KO Lin− cells across time points. Fold-change vs. WT is shown. Welch two sample t-test.

B. Expression levels of selected MDS/AML signature genes (reported as commonly mutated in the literature) in Tet2 Mut and KO Lin− cells across time points. Fold-change vs. WT is shown. Welch two sample t-test.

C. Heatmap showing lymphoma and MDS/AML signature genes downregulated in Tet2 KO Lin− cells at 6 months. Relative expression levels from normalized counts are shown. * indicated genes containing a hyper-DMR (per the analyses in figure 5).