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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: J Mol Cell Cardiol. 2023 May 23;181:33–45. doi: 10.1016/j.yjmcc.2023.05.007

Figure 4. Short-term Emre deletion preserves cardiac function in I/R.

Figure 4.

Three weeks post-tamoxifen, mouse hearts were subjected to 20 minutes of stabilization, 20 minutes of global ischemia and 90 minutes of reperfusion. At 5, 30, 60, and 90 minutes after the onset of reperfusion, relative to baseline pre-ischemia, A) rate pressure product (RPP) = heart rate (HR) × left ventricular pressure (LVP), B) dP/dtmax, C) dP/dtmin, and D) creatine kinase (CK) release were assessed. Values at 90 minutes: A) RPP: MCM+: 50.96% ± 17.39, Emrefl/fl: 44.55% ± 13.05 and EmrecKO: 87.64% ± 26.68. B) dP/dtmax: MCM+: 48.50% ± 13.10, Emrefl/fl: 47.14% ± 6.74 and EmrecKO: 72.04% ± 16.62. C) dP/dtmin: MCM+: 48.53% ± 11.95, Emrefl/fl: 47.64% ± 6.45 and EmrecKO: 67.88% ± 14.23. Values represent mean ± SD. *p<0.05, n=5–6 per group. Two-way ANOVA test was used for statistical analysis.