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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: Histopathology. 2023 Jun 12;83(3):492–495. doi: 10.1111/his.14973

Figure 2. Immunophenotypic and genetic features.

Figure 2.

(A) The tumor cells are positive for CD3 (400×). (B) The tumor cells are positive for T-cell receptor-δ and negative for T-cell receptor-β (beta-F1; inset; both, 400×). (C) The tumor cells show strong, uniform nuclear staining for p63 (400×). Other immunophenotypic markers are described in the text. (D) Breakapart FISH for the JAK2 locus (9p24) shows separation of the 3’ red signals and 5’ green signals (1000×), indicating the presence of a rearrangement. (E) Breakapart FISH for the TP63 locus (3q28) shows separation of the 5’ red signals and 3’ green signals (1000×), indicating the presence of a rearrangement. (F) Dual-color, dual-fusion FISH for the TP63 locus (3q28; red) and the TBL1XR1 locus (3q26.32; green) shows two yellow fusion signals (1000×), consistent with the classic 3q inversion, inv(3)(q26q28).