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. Author manuscript; available in PMC: 2023 Sep 27.
Published in final edited form as: J Hum Genet. 2023 Apr 18;68(8):565–570. doi: 10.1038/s10038-023-01147-z

Figure 2.

Figure 2.

Associations between phenotypes and genes harboring rare variants

Rare variants: rare (minor allele frequency [MAF] < 0.1% and Population Maximum MAF < 0.1%) loss-of-function variants. AF: atrial fibrillation. T2D: type 2 diabetes. LDL: low-density lipoprotein. AoU: the All of Us research program. UKB: UK Biobank. N carriers: number of participants who carry at least one rare variant within each gene. Results are presented in forest plots, with effect sizes (odds ratios [OR] for AF and T2D, betas for height and LDL) and 95% confidence intervals (95% CI). ORs were plotted on a logarithmic scale.