Fig. 2.

a Nephron tubule dimensions, showing location and size of initial mutant cell domain (yellow); WT cells occupy the orange domain. b Finite element mesh of quarter-model, with 128 uniformly distributed elements along the circumferential direction, 4 uniformly distributed elements along the radial direction, and 50 non-uniformly distributed elements along the axial direction. This mesh was used for apical-basal radial (ABR) and basolateral isotropic (BLI) contraction (yellow). Insets show mesh partitioning for models that used basal (BTI) and apical (ATI) transversely isotropic contraction (pink). In all cases, cell proliferation was prescribed in the yellow domain only