Table 1.

Summary of the 54 finite element models analyzed in this study. In all cases $E^{WT}=1$ kPa. (a) Models where WT and mutant cells have the same modulus. (b) Models where mutant cells have a modulus ten times smaller than WT cells. ABR: apical-basal uniaxial contraction, BLI: basolateral isotropic contraction, ATI: apical transversely isotropic contraction. CCP: cell contraction then proliferation, CPC: cell proliferation then contraction, SCP: simultaneous contraction and proliferation. Cyst formation (Y=yes, N=no) based on visual inspection of models at final analysis time (Figs. 3 and 4)

$E^{WT}:E^{MC}$	$T_0:E^{MC}$	Contraction	Sequence	Model label	% Completion	Cyst formed
1 : 1	10 : 1	ABR	CCP	F1111	57.3	Y
			CPC	F1112	36.6	N
			SCP	F1113	55.5	Y
		BLI	CCP	F1121	36.8	N
			CPC	F1122	36.6	N
			SCP	F1123	37.2	N
		ATI	CCP	F1131	57.1	N
			CPC	F1132	39.1	N
			SCP	F1133	56.5	N
		BTI	CCP	F1141	53.6	N
			CPC	F1142	38.7	N
			SCP	F1143	51.6	N
	1 : 1	ABR	CCP	F1211	38.3	N
			CPC	F1212	36.6	N
			SCP	F1213	32.6	N
		BLI	CCP	F1221	36.8	N
			CPC	F1222	36.6	N
			SCP	F1223	34.3	N
		ATI	CCP	F1231	70.8	N
			CPC	F1232	39.1	N
			SCP	F1233	69.7	N
		BTI	CCP	F1241	46.7	N
			CPC	F1242	38.7	N
			SCP	F1243	44.6	N
	0 : 1	ABR	SCP	F1313	38.1	N
		BLI	SCP	F1323	38.1	N
		ATI	SCP	F1333	40.6	N
		BTI	SCP	F1343	40.2	N
$E^{WT}:E^{MC}$	$T_0:E^{MC}$	Contraction	Sequence	Model label	% Completion	Cyst formed
10 : 1	10 : 1	ABR	CCP	F2111	100.0	Y
			CPC	F2112	45.9	N
			SCP	F2113	100.0	Y
		BLI	CCP	F2121	37.7	N
			CPC	F2122	45.9	N
			SCP	F2123	35.2	N
		ATI	CCP	F2131	67.5	N
			CPC	F2132	42.4	N
			SCP	F2133	66.2	N
		BTI	CCP	F2141	53.9	N
			CPC	F2142	46.9	N
			SCP	F2143	50.3	N
	1 : 1	ABR	CCP	F2211	47.0	N
			CPC	F2212	45.9	N
			SCP	F2213	48.8	N
		BLI	CCP	F2221	49.0	N
			CPC	F2222	45.9	N
			SCP	F2223	47.0	N
		ATI	CCP	F2231	50.1	N
			CPC	F2232	42.4	N
			SCP	F2233	47.7	N
		BTI	CCP	F2241	49.8	N
			CPC	F2242	46.9	N
			SCP	F2243	49.4	N
	0 : 1	ABR	SCP	F2313	47.6	N
		BLI	SCP	F2323	47.6	N
		ATI	SCP	F2333	44.1	N
		BTI	SCP	F2343	48.7	N