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Transcriptomic analyses of primary murine osteosarcomas show that transcriptomes of those expressing p53 missense mutations differ significantly from those that do not express p53. A and B: Volcano plots showing distribution of gene expression differences in Op53R172H/− and Op53R245W/− osteosarcomas, respectively. C and D: Heatmaps showing differential expression of top 100 genes ranked by absolute LFC in Op53R172H/− v. Op53−/− and Op53R245W/− v. Op53−/− osteosarcomas, respectively.
