Figure 3:

Transcriptomes regulated by p53R172H and p53R245W mutants are different. A: Venn diagram showing minimal intersection of the differentially expressed genes in Op53^R172H/− (red) and Op53^R245W/− (green) osteosarcomas, p = 1.00E+00. B: Dysregulated pathways in Op53^R245W/− compared to Op53^R172H/−, based on differing -log(P-value). C and D: Circos plots depicting the differentially upregulated genes in Op53^R172H/− and Op53^R245W/− osteosarcomas, and the list of transcription factors, arranged by significance, binding to enriched motifs in a 10kb region upstream of the transcription start sites of differentially upregulated genes.