Table 1:
Transcription factors (TFs) with enriched motifs in p53 mutant osteosarcomas. Colored TFs (purple) were identified in analysis excluding outliers (Supplementary Figure 3B). Asterisks represent TFs known to interact with mutant p53 in published studies.
| TFs with enriched motifs in p53R172H tumors |
q-value | TFs with enriched motifs in p53R245W tumors |
q-value |
|---|---|---|---|
| EGR2 | 8.88E-11 | KLF15 | 7.38E-06 |
| NR1D2 | 2.84E-09 | MAZ | 7.74E-06 |
| E2F6 | 6.48E-07 | FLI1 | 1.01E-05 |
| ETS1* | 2.68E-06 | SP5 | 0.00019677 |
| SP2 | 5.76E-05 | WT1 | 0.00019677 |
| FOXL2 | 5.76E-05 | SPP1* | 0.00066578 |
| ETS2* | 0.0005007 | IRF3 | 0.00246145 |
| RARA | 0.00091714 | STAT3* | 0.00246145 |
| STAT1 | 0.00120136 | VDR* | 0.00295375 |
| TFDP1 | 0.00458336 | ETV5 | 0.00365936 |
| SALL4 | 0.00530985 | SP4 | 0.00592509 |