Table 1.

Overview of transcriptomic data sets selected for our comparison of three rupture systems.

Data set	Rupture System	Results	Method	Organism	Sample details	GEO accession number
Kurki et al. (2011)	Intracranial aneurysm (ICA)	1,426 DEGs between ruptured and unruptured ICA walls	Microarray	Human	11 ruptured and 8 unruptured saccular ICA vascular walls	GSE13353
Nhan-Chang et al. (2010)	Chorioamniotic membrane rupture	677 DEGs between the ruptured zone above the cervix and a distal site after spontaneous rupture of membranes at term	Microarray	Human	20 matched sets of tissue samples of the chorion and amnion from the site of chorioamniotic membrane rupture and a region distant from the rupture site	–
Liu et al. (2017)	Ovulation	2,888 DEGs between preovulatory follicles and anovulatory follicles from a Pgr-KO model	RNAseq	Zebrafish	Isolated follicular cells (theca and granulosa) from three wildtype and three Pgr-KO female zebrafish prior to ovulation	–
Park et al. (2020)	Ovulation	720 DEGs between mural granulosa cells from Esr2-Pgr-KO mice and wildtype mice 6 h after ovulation	Single-cell RNAseq	Mouse	Single cell dissociation of eight ovaries from wildtype C57BL/6 mice and Esr2-Pgr-KO mice 6 h after induction of ovulation with hCG, differentially expressed gene list based on ovulatory mural granulosa cells	GSE145107

GEO, gene expression omnibus; DEG, differentially expressed gene; Esr, estrogen receptor; hCG, human chorionic gonadotropin; KO, knockout; Pgr, progestin receptor; RNAseq, RNA sequencing.