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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: Alzheimers Dement. 2023 Jun 12;19(9):4150–4162. doi: 10.1002/alz.13347

Figure 3. Variance of declining cognitive, motor abilities and daily physical activity accounted for by ADRD brain pathologies.

Figure 3.

This figure summarizes the additional variance of decline explained by the measures of nine brain pathologies (blue) as compared to a model with demographic measures age, sex, and education and their interaction with the annual rate of change alone for each of the three phenotypes. The majority of decline especially for motor phenotypes remained unexplained.