Table 4.

Associations of brain pathologies with level and rate of change in daily physical activity, motor abilities and cognition ^*

Pathology	Daily Physical Activity Estimate, (SE), p-Value		Motor Abilities Estimate, (SE), p-Value		Cognition Estimate, (SE), p-Value
	Level before death	Rate of decline	Level before death	Rate of decline	Level before death	Rate of decline
Parkinson’s disease pathology	−0.379 (0.220) 0.085	−0.048 (0.029) 0.101	−0.113, (0.047) 0.015*	−0.021 (0.007) 0.002*	−0.652, (0.185) <0.001*	−0.081 (0.020) <0.001*
Alzheimer’s disease pathology	0.077 (0.086) 0.371	−0.007 (0.010) 0.530	−0.037, (0.018) 0.034*	−0.003 (0.002) 0.256	−0.964 (0.073) <0.001*	−0.100 (0.008) <0.001*
TDP-43	−0.018 (0.109) 0.869	0.005 (0.013) 0.674	−0.006 (0.022) 0.770	−0.005 (0.003) 0.103	−0.245 (0.093) 0.009*	−0.020 (0.010) 0.038*
Hippocampal Sclerosis	−0.386 (0.175) 0.027*	−0.029 (0.020) 0.144	−0.108 (0.037) 0.003*	−0.010 (0.004) 0.020*	−0.832 (0.148) <0.001*	−0.057 (0.015) <0.001*
Macroinfarcts	−0.200 (0.105) 0.056	−0.023 (0.013) 0.074	−0.010 (0.021) 0.135	−0.0001 (0.003) 0.761	−0.093 (0.100) 0.303	−0.011 (0.009) 0.256
Microinfarcts	−0.015 (0.102) 0.879	0.011 (0.012) 0.345	−0.051 (0.021) 0.015*	−0.002 (0.003) 0.543	−0.143 (0.088) 0.103	−0.006 (0.009 0.528
Atherosclerosis	−0.093 (0.121) 0.439	−0.003 (0.015) 0.851	−0.037 (0.025) 0.134	−0.002 (0.003) 0.517	−0.179 (0.104) 0.085	−0.014 (0.012) 0.187
Arteriolosclerosis	−0.083 (0.113) 0.461	−0.019 (0.013) 0.146	−0.060 (0.023) 0.010*	−0.005 (0.003) 0.102	−0.203 (0.100) 0.036*	−0.022 (0.010) 0.027*
Cerebral amyloid angiopathy	−0.170 (0.107) 0.112	−0.027 (0.013 0.013*	−0.012 (0.022) 0.568	−0.006 (0.003) 0.039*	0.027 (0.091) 0.764	−0.004 (0.009) 0.642

^*Estimated from a single trivariate random coefficient model which included terms for baseline and rate of change in total daily physical activity, motor abilities and cognition from 477 decedents with postmortem brain exam. This model included terms for demographics (age, sex, education) and 9 indices of ADRD pathologies and their interactions with the rate of change in in total daily physical activity, motor abilities and cognition. Each column shows the associations for the nine pathologies and the level and rate of decline for one of the three clinical phenotypes. Each cell shows the estimate, standard error (S.E.) and p-Value for either the association of the level of function at the last visit before death or the rate of clinical decline during the study and their association with the pathology listed in the beginning of the row in the left-hand column. P-values <0.05 are bolded. The terms for time before death, age, sex and education and their interaction with time before death that were included in the model are not shown.