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Knockdown of LMNA decreased protein levels of AKT1/p-AKT1 and β-catenin in 786-O and SN12C cells. a) AKT1, p-AKT1 andβ-catenin levels were reduced after knockdown of LMNA in 786-O cells and SN12C cells respectively, but PI3K level was increased; b) Western blotting results were quantified. GAPDH was used as an internal reference for normalization; c) the relative p-AKT/AKT level was examined for both cell lines. (*p < .05; **p < .01; ***p < .001).
