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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: HLA. 2023 Jun 7;102(2):206–212. doi: 10.1111/tan.15126

Table 1.

Examples of Allele Ambiguity for the HLA and KIR Genes

Locus Identical Gene Feature1 Ambiguous Alleles Group2
HLA-DRB1 Exon 2 DRB1*01:01:01:01, DRB1*01:01:01:02, DRB1*01:01:01:03, DRB1*01:01:01:04, DRB1*01:01:01:05, DRB1*01:01:01:06, DRB1*01:01:01:07, DRB1*01:01:01:08, DRB1*01:01:01:09, DRB1*01:01:01:10, DRB1*01:01:01:11, DRB1*01:01:01:12, DRB1*01:01:01:13, DRB1*01:01:01:14, DRB1*01:01:01:15, DRB1*01:01:01:16, DRB1*01:01:01:17, DRB1*01:01:01:18, DRB1*01:01:01:19, DRB1*01:01:32, DRB1*01:01:33, DRB1*01:01:35, DRB1*01:01:37, DRB1*01:01:39, DRB1*01:01:41, DRB1*01:01:44, DRB1*01:50, DRB1*01:67, DRB1*01:77, DRB1*01:82, DRB1*01:91Q, DRB1*01:95, DRB1*01:98, DRB1*01:100, DRB1*01:103, DRB1*01:104, DRB1*01:107, DRB1*01:115, DRB1*01:117, DRB1*01:119, DRB1*01:120, DRB1*01:121, DRB1*01:128, DRB1*01:129, DRB1*01:132, DRB1*01:137 and DRB1*01:139 HLA-DRB1*01:01:01G
HLA-A Exons 2 & 3 A*23:01:01:01, A*23:01:01:02, A*23:01:01:03, A*23:01:01:04, A*23:01:01:05, A*23:01:01:06, A*23:01:01:07, A*23:01:01:08, A*23:01:01:09, A*23:01:01:10, A*23:01:01:11, A*23:01:01:12, A*23:01:01:13, A*23:01:01:14, A*23:01:01:15, A*23:01:01:16, A*23:01:01:17, A*23:01:01:18, A*23:01:01:19, A*23:01:01:20, A*23:01:01:21, A*23:01:01:22, A*23:01:01:23, A*23:01:01:24, A*23:01:01:25, A*23:01:01:26, A*23:01:01:27, A*23:01:01:28, A*23:01:01:29, A*23:01:01:30, A*23:01:05, A*23:01:19, A*23:01:24, A*23:01:25, A*23:01:27, A*23:01:28, A*23:01:31, A*23:01:34, A*23:07N, A*23:17:01:01, A*23:17:01:02, A*23:17:01:03, A*23:17:01:04, A*23:17:02, A*23:18, A*23:20, A*23:58, A*23:85, A*23:86, A*23:87, A*23:88, A*23:91N, A*23:92, A*23:93, A*23:94, A*23:95, A*23:96, A*23:103N, A*23:115, A*23:116, A*23:117, A*23:118, A*23:121, A*23:123 and A*23:125 HLA-A*23:01:01G
KIR2DL5 Exons 3, 5, 7, 8 & 9 KIR2DL5A*001, KIR2DL5B*006, KIR2DL5B *008 and KIR2DL5A*012 KIR2DL5*0013
KIR3DL2 Exons 3, 4, 5, 7, 8 & 9 KIR3DL2*002, KIR3DL2*101 and KIR3DL2*102 KIR3DL2*0023
1:

Gene Features are the structural elements of a gene – Introns, Exons and Untranslated Regions (UTRs)[27].

2:

Groups are identifiers that represent sets of alleles sharing a predefined set of gene features. For the HLA alleles, “G groups” (e.g., HLA-DRB1*01:01:01G) represent all of the alleles with identical sequence for exons 2 and 3 for class I HLA alleles, and exon 2 for class II HLA alleles. G group membership described here is specific to IPD-IMGT/HLA Database Release 3.50.0.

3:

For KIR alleles, the KIR2DL5*001 and KIR3DL2*002 groups represent all alleles that share identical sequence for KIR exons 3–5 and 7–9 with KIR2DL5A*001 and KIR3DL2*002, respectively[28]. The KIR allele group memberships described here are specific to the KIR typing approach described by Wagner et al., 2018[19]. The use of the KIR2DL5 designation without specifying the A or B ending is not consistent with the official KIR nomenclature.