Table 3.

The risk of dementia associated with parental history of dementia

	Number of participants				Risk of dementia*			Risk of AD†			Risk of VaD†			Risk of OD†
	Control	Dementia	AD	VaD	OR	95% CI	p	OR	95% CI	p	OR	95% CI	p	OR	95% CI	p
Model 1‡
None	14674	767	531	144	1.00			1.00			1.00			1.00
Parental	1659	94	74	12	1.47	1.15–1.86	0.002	1.72	1.31–2.26	<0.001	0.99	0.54–1.81	0.963	0.92	0.44–1.93	0.822
Model 2§
None	7938	358	245	63	1.00			1.00			1.00			1.00
Parental	1055	46	41	2	1.13	0.80–1.59	0.482	1.54	1.06–2.23	0.023	0.27	0.07–1.13	0.073	0.50	0.15–1.62	0.245

OR, odds ratio; CI, confidence intervals; AD, Alzheimer’s disease; VaD, Vascular dementia, OD; Other dementia

^*binary logistic regression analyses

^†multinomial logistic regression analyses

^‡adjusted for age, educational level, hypertension, diabetes mellitus and cohort as covariates

^§adjusted for age, educational level, hypertension, diabetes mellitus, cohort and the presence of APOE ε4 allele as covariates