Table 4.

The risk of dementia associated with paternal and maternal history of dementia

	Number of participants				Risk of dementia*			Risk of AD†			Risk of VaD†			Risk of OD†
	Control	Dementia	AD	VaD	OR	95% CI	p	OR	95% CI	p	OR	95% CI	p	OR	95% CI	p
APOE ε4 unadjusted‡
Paternal
No	15860	835	586	152	1.00			1.00			1.00			1.00
Yes	473	26	19	4	1.35	0.88–2.07	0.173	1.45	0.88–2.38	0.144	1.07	0.39–2.95	0.898	1.22	0.38–3.95	0.739
Maternal
No	15069	787	545	147	1.00			1.00			1.00			1.00
Yes	1264	74	60	9	1.51	1.15–1.97	0.003	1.80	1.33–2.43	<0.001	1.02	0.51–2.03	0.966	0.76	0.31–1.90	0.559
APOE ε4 adjusted§
Paternal
No	8721	392	276	65	1.00			1.00			-			1.00
Yes	272	12	10	0	1.20	0.64–2.25	0.561	1.50	0.75–2.98	0.252	-	-	-	1.38	0.32–5.94	0.663
Maternal
No	8157	366	251	63	1.00			1.00			1.00			1.00
Yes	836	38	35	2	1.19	0.82–1.72	0.361	1.64	1.10–2.44	0.014	0.37	0.09–1.54	0.171	0.22	0.03–1.57	0.130

OR, odds ratio; CI, confidence intervals; AD, Alzheimer’s disease; VaD, Vascular dementia; OD, Other dementia

The risk of paternal history of dementia on the risk of VaD could not be estimated because there was no vascular dementia patients with parental history of dementia

^*binary logistic regression analyses

^†multinomial logistic regression analyses

^‡adjusted for age, educational level, hypertension, diabetes mellitus and cohort as covariates

^§adjusted for age, educational level, hypertension, diabetes mellitus, cohort and the presence of APOE ε4 allele as covariates