Table 1.
Comparison of demographic and clinical risk factors used in the risk prediction model for detection of gastric intestinal metaplasia for the development and validation cohorts
| Development Cohort (MEDVAMC) | Validation Cohort (CHI-St. Luke’s) | |||||
|---|---|---|---|---|---|---|
| Cases n=423(%) |
Controls n=1796 (%) |
p-value | Cases n=215 (%) |
Controls n=2469 (%) |
p-value | |
| Sex | <0.001 | 0.543 | ||||
| Male | 411 (97.16) | 1630 (90.76) | 92 (42.79) | 1004 (40.66) | ||
| Female | 12 (2.84) | 166 (9.24) | 123 (57.21) | 1465 (59.34) | ||
| Age | <0.001 | <0.001 | ||||
| <60 | 138 (32.62) | 761 (42.37) | 90 (41.86) | 1418 (57.43) | ||
| 60–69 | 218 (51.54) | 842 (46.88) | 72 (33.49) | 589 (23.86) | ||
| ≥70 | 67 (15.84) | 193 (10.75) | 53 (24.65) | 462 (18.71) | ||
| Race/Ethnicity | <0.001 | <0.001 | ||||
| White | 175 (41.37) | 1095 (60.97) | 88 (40.93) | 1431 (57.96) | ||
| Hispanic | 62 (14.66) | 148 (8.24) | 56 (26.05) | 425 (17.21) | ||
| Black | 178 (42.08) | 521 (29.01) | 44 (20.47) | 413 (16.73) | ||
| Asian | - | - | 22 (10.23) | 133 (5.39) | ||
| Other/Unknown | 8 (1.89) | 32 (1.78) | 5 (2.33) | 67 (2.71) | ||
| Habitual smoker | <0.001 | 0.031 | ||||
| No | 267 (63.12) | 1219 (67.87) | 173 (80.47) | 2120 (85.86) | ||
| Yes | 138 (32.62) | 473 (26.34) | 42 (19.53) | 206 (8.34) | ||
| Unknown/missing | 18 (4.26) | 104 (5.79) | 0 (0.00) | 0 (0.00) | ||
| Helicobacter pylori | <0.001 | <0.001 | ||||
| No | 199 (47.04) | 1377 (76.67) | 164 (76.28) | 2199 (89.06) | ||
| Yes | 219 (51.77) | 394 (21.94) | 51 (23.72) | 270 (10.94) | ||
| Unknown/missing | 5 (1.18) | 25 (1.39) | 0 (0.00) | 0 (0.00) | ||
| PPI use | 0.017 | 0.167 | ||||
| No | 205 (48.46) | 734 (40.87) | 172 (80.00) | 1865 (75.54) | ||
| Yes | 193 (45.63) | 935 (52.06) | 43 (20.00) | 595 (24.10) | ||
| Unknown/missing | 25 (5.91) | 127 (7.07) | 9 (0.36) | |||
PPI: proton pump inhibitor