Table 1 – Immune based classifications of iCCA.
Subtypes of iCCA identified include immune-infiltrated, immune altered, or immune excluded/immunosuppressive.
| Immune-infiltrated | Immune-altered, Immunosuppressive infiltrate | Immune-excluded | |
|---|---|---|---|
| TME-Based iCCA Classification16 | |||
| Immune Desert | 46-48% | ||
| Immunogenic | 9-13% | ||
| Myeloid-rich | 13-19% | ||
| Mesenchymal | 22-28% | ||
| Total % of iCCAs | 31-41% | 13-19% | 46-48% |
| iCCA Stroma, Tumor, and Immune Microenvironment Classification17 | |||
| Immune Classical | 10% | ||
| Inflammatory Stroma | 25% | ||
| Hepatic Stem-Like | 35% | ||
| Tumor Classical | 10% | ||
| Desert-like | 20% | ||
| Total % of iCCAs | 10% | 60% | 30% |
| TLS-Based iCCA Classification20 | |||
| Class I – TLS predominantly in peri-tumoral region | 28.1% | ||
| Class II – Heterogeneous distribution of TLS, majority in peritumor region | 31.1% | ||
| Class III – Heterogeneous distribution of TLS, majority in intra-tumor region | 28.4% | ||
| Class IV – TLS predominantly in intra-tumoral region | 12.5% | ||
| Total % of iCCAs | 12.5% | 59.5% | 28.1 % |
iCCA, intrahepatic cholangiocarcinoma; TLS, tertiary lymphoid structures; TME, tumor microenvironment