Table 3:

Effect of Alcohol Use Disorder Polygenic Risk Score on Age of Onset and Progression of Alcohol-Related Measures by Population Group

	European Ancestry							African Ancestry
Outcome Measure	B	SE	HR	95% CI	P-Value	Adjusted P-Value	R2	B	SE	HR	95% CI	P-Value	Adjusted P-Value	R2
Age of First Use	0.057	0.014	1.06	1.03–1.09	<0.001	<0.001	0.3%	0.015	0.017	1.02	0.98–1.05	0.382	0.382	0.0%
Age of Regular Use	0.060	0.015	1.06	1.03–1.10	<0.001	<0.001	0.3%	0.046	0.018	1.05	1.01–1.09	0.013	0.039	0.1%
Age First Brought Up Problems	0.173	0.023	1.19	1.14–1.24	<0.001	<0.001	1.0%	0.065	0.027	1.07	1.01–1.13	0.019	0.057	0.1%
Age of Diagnosis of AD	0.136	0.019	1.15	1.10–1.19	<0.001	<0.001	0.8%	0.086	0.023	1.09	1.04–1.14	0.0002	0.001	0.2%
Regular Use to Brought Up Problems	0.133	0.024	1.14	1.09–1.20	<0.001	<0.001	0.6%	0.034	0.029	1.04	0.98–1.09	0.236	0.382	0.0%
Regular Use to AD Diagnosis	0.096	0.021	1.10	1.06–1.15	<0.001	<0.001	0.4%	0.061	0.025	1.06	1.01–1.12	0.015	0.045	0.1%

Note: All models include sex, age, and the first 10 ancestry principal components. Progression models (Regular Use to …) also include Age of Regular Use as a covariate and the interaction between time and Age of Regular Use because the proportional hazards assumption was violated. Events=number of individuals meeting the milestone or progression event, SE=standard error, HR=hazard ratio, 95%CI=95% confidence interval, R²=incremental pseudo R-squared, AD=alcohol dependence