Table 4:

Effect of Alcohol Use Disorder Polygenic Risk Score in Cox Proportional Hazard Models of Alcohol-Related Time-to-Event and Progression Measures by Sex among Individuals of European Ancestry

	Male							Female
Outcome Measure	B	SE	HR	95% CI	P-Value	Adjusted P-Value	R2	B	SE	HR	95% CI	P-Value	Adjusted P-Value	R2
Age of First Use	0.057	0.019	1.06	1.02–1.10	0.003	0.005	0.3%	0.060	0.022	1.06	1.02–1.10	0.006	0.006	0.3%
Age of Regular Use	0.056	0.020	1.06	1.02–1.10	0.005	0.005	0.3%	0.070	0.024	1.07	1.02–1.13	0.004	0.006	0.4%
Age First Brought Up Problems	0.136	0.027	1.15	1.09–1.21	<0.0001	0.0005	0.8%	0.264	0.041	1.30	1.20–1.41	<0.0001	0.0004	1.7%
Age of AD Diagnosis	0.123	0.024	1.13	1.08–1.19	<0.0001	0.0005	0.8%	0.171	0.034	1.19	1.11–1.27	<0.0001	0.0004	1.0%
Regular Use to Brought Up Problems	0.089	0.029	1.09	1.03–1.16	0.002	0.0045	0.3%	0.234	0.044	1.27	1.16–1.38	<0.0001	0.0004	1.5%
Regular Use to AD Diagnosis	0.085	0.026	1.09	1.04–1.15	0.001	0.004	0.4%	0.127	0.039	1.14	1.05–1.23	0.001	0.003	0.6%

Note: All models include sex, age, and the first 10 ancestry principal components. Progression models (Regular Use to …) also include Age of Regular Use as a covariate and the interaction between time and Age of Regular Use because the proportional hazards assumption was violated. Events=number of individuals meeting the milestone or progression event, SE=standard error, HR=hazard ratio, 95%CI=95% confidence interval, R² = incremental pseudo R-squared, AD=alcohol dependence