Table 5:

Effect of Opioid Use Disorder Polygenic Risk Score in Cox Proportional Hazard Models of Opioid-Related Time-to-Event and Progression Measures by Population Group

	European Ancestry							African Ancestry
Outcome Measure	B	SE	HR	95% CI	P-Value	Adjusted P-Value	R2	B	SE	HR	95% CI	P-Value	Adjusted P-Value	R2
Age of First Use	0.135	0.019	1.14	1.10–1.19	<0.0001	0.0002	0.9%	0.069	0.027	1.07	1.02–1.13	0.010	0.060	0.1%
Age of Regular Use	0.150	0.021	1.16	1.11–1.21	<0.0001	0.0002	0.9%	0.034	0.033	1.03	0.97–1.10	0.312	0.936	0.0%
Age First Brought Up Problems	0.177	0.023	1.19	1.14–1.25	<0.0001	0.0002	1.1%	0.037	0.039	1.04	0.96–1.12	0.345	0.936	1.0%
Age of OD Diagnosis	0.173	0.022	1.19	1.14–1.24	<0.0001	0.0002	1.1%	0.052	0.036	1.05	0.98–1.13	0.150	0.600	0.0%
Regular Use to Problems	0.054	0.027	1.06	1.00–1.11	0.045	0.090	0.2%	0.003	0.047	1.00	0.92–1.10	0.942	0.942	0.0%
Regular Use to OD Diagnosis	0.035	0.034	1.04	0.97–1.11	0.316	0.316	0.0%	−0.028	0.058	0.97	0.87–1.09	0.624	0.942	0.0%

Note: All models include sex, age, and the first 10 ancestry principal components. Progression models (Reg Use to …) also include Age of Regular Use as a covariate and the interaction between time and Age of Regular Use because the proportional hazards assumption was violated. Events=number of individuals meeting the milestone or progression event, SE=standard error, HR=hazard ratio, 95%CI=95% confidence interval, R² = incremental pseudo R-squared, OD=opioid dependence