Table 2.
TED and Associated Factors Among IRIS® Registry Patients (2013-2018): Univariable and Multivariable Logistic Regression Analyses
| Univariable | Multivariable* | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristic | TED Patients | Patients without TED | OR | 95% CI | P-Value | OR | 95% CI | P-Value | |||
| N | (%) | N | (%) | ||||||||
| All Patients | 42,211 | (100) | 47,831,344 | (100) | |||||||
| Age Group (years) | 18-<30 | 1,441 | (3) | 4,206,622 | (9) | [Ref] | [Ref] | ||||
| 30-39 | 2,997 | (7) | 3,691,077 | (8) | 2.37 | (2.23, 2.52) | < 0.0001 | 2.20 | (2.06, 2.35) | < 0.0001 | |
| 40-49 | 5,403 | (13) | 5,111,651 | (11) | 3.09 | (2.91, 3.27) | < 0.0001 | 2.91 | (2.74, 3.09) | < 0.0001 | |
| 50-59 | 10,138 | (25) | 8,243,992 | (17) | 3.59 | (3.40, 3.79) | < 0.0001 | 3.26 | (3.08, 3.45) | < 0.0001 | |
| 60-69 | 12,076 | (29) | 11,636,003 | (24) | 3.03 | (2.87, 3.20) | < 0.0001 | 2.69 | (2.54, 2.85) | < 0.0001 | |
| 70+ | 9,156 | (22) | 14,941,999 | (31) | 1.79 | (1.69, 1.89) | < 0.0001 | 1.55 | (1.46, 1.64) | < 0.0001 | |
| Gender | Male | 7,450 | (18) | 20,300,768 | (42) | [Ref] | [Ref] | ||||
| Female | 33,761 | (82) | 27,530,576 | (58) | 3.34 | (3.26, 3.43) | < 0.0001 | 3.48 | (3.39, 3.57) | < 0.0001 | |
| Race | White | 30,039 | (73) | 30,842,240 | (64) | [Ref] | [Ref] | ||||
| Asian | 1,050 | (3) | 1,408,548 | (3) | 0.77 | (0.72, 0.81) | < 0.0001 | 0.90 | (0.85, 0.96) | 0.002 | |
| Black or African American | 4,053 | (10) | 3,479,445 | (7) | 1.20 | (1.16, 1.24) | < 0.0001 | 1.19 | (1.15, 1.23) | < 0.0001 | |
| Other | 464 | (1) | 490,870 | (1) | 0.97 | (0.89, 1.06) | 0.52 | 1.06 | (0.96, 1.16) | 0.26 | |
| Unknown | 5,605 | (14) | 11,610,241 | (24) | 0.50 | (0.48, 0.51) | < 0.0001 | 0.70 | (0.67, 0.72) | < 0.0001 | |
| Ethnicity | Not Hispanic | 32,267 | (78) | 31,414,516 | (66) | [Ref] | [Ref] | ||||
| Hispanic | 1,849 | (4) | 3,577,173 | (7) | 0.50 | (0.48, 0.53) | < 0.0001 | 0.68 | (0.65, 0.72) | < 0.0001 | |
| Unknown | 7,095 | (17) | 12,839,655 | (27) | 0.54 | (0.52, 0.55) | < 0.0001 | 0.68 | (0.66, 0.70) | < 0.0001 | |
| Geographic Region | South | 10,411 | (25) | 13,547,719 | (28) | [Ref] | [Ref] | ||||
| Midwest | 8,516 | (21) | 7,367,032 | (15) | 1.50 | (1.46, 1.55) | < 0.0001 | 1.43 | (1.39, 1.47) | < 0.0001 | |
| Northeast | 6,677 | (16) | 7,540,566 | (16) | 1.15 | (1.12, 1.19) | < 0.0001 | 1.20 | (1.17, 1.24) | < 0.0001 | |
| West | 5,532 | (13) | 7,251,763 | (15) | 0.99 | (0.96, 1.03) | 0.66 | 1.15 | (1.11, 1.19) | < 0.0001 | |
| Unknown | 10,075 | (24) | 12,124,264 | (25) | 1.08 | (1.05, 1.11) | < 0.0001 | 1.14 | (1.11, 1.18) | < 0.0001 | |
| Type I Diabetes Mellitus | No | 39,998 | (97) | 47,006,176 | (98) | [Ref] | [Ref] | ||||
| Yes | 1,213 | (3) | 825,168 | (2) | 1.73 | (1.63, 1.83) | < 0.0001 | 1.87 | (1.76, 1.98) | < 0.0001 | |
| Type II Diabetes Mellitus | No | 34,851 | (85) | 39,047,474 | (82) | [Ref] | [Ref] | ||||
| Yes | 6,360 | (15) | 8,783,870 | (18) | 0.81 | (0.79, 0.83) | < 0.0001 | 0.78 | (0.76, 0.8) | < 0.0001 | |
| Smoking Status | No | 21,220 | (51) | 27,894,433 | (58) | [Ref] | [Ref] | ||||
| Former | 9,523 | (23) | 8,466,064 | (18) | 1.48 | (1.44, 1.51) | < 0.0001 | 1.64 | (1.6, 1.68) | < 0.0001 | |
| Current | 7,598 | (18) | 4,669,700 | (10) | 2.14 | (2.08, 2.20) | < 0.0001 | 2.16 | (2.1, 2.22) | < 0.0001 | |
Abbreviations: TED = Thyroid Eye Disease; OR = Odds Ratio; CI = Confidence Interval; IRIS = Intelligent Research in Sight; Ref = Reference.
*
Multivariable logistic regression model contained all of the above factors (age group, gender, geographic region, race, ethnicity, smoking status, Type I diabetes, Type II diabetes). Patients with unknown smoking status were excluded from the analyses (TED Patients (N=2870); Patients w/o TED (N=6,801,147). Bolded variables represent statistical significance (p<0.05).