TABLE 1.

Characteristics of the three Wilson's disease patients with copper deficiency at Wilson's disease diagnosis

Patients	1	2	3
Gender	Male	Male	Male
At Wilson's disease diagnosis
Age (years)	34	58	23
Mutation 1	His1069Gln‐exon14	Phe714Leu‐exon8	Thr977Met‐ex13
Mutation 2	Pro1098Arg‐exon15	deletion‐exon 4	Ile1148Thr‐ex16
Clinical form of WD	Hepatic + KFR	Hepatic and neurologic	Presymptomatic
UWDRS	0	3 (writer cramp)	0
Hepatic score (0–6)	5 (compensated cirrhosis, platelets 70,000/mm4)	3 (mild cirrhosis, no cytopenia)	0
Ophthalmologic score (0–2)	2	0	0
Brain MRI	Normal	Normal	Normal
Treatments	zinc acetate (150 mg/day)	D‐Penicillamine 900 mg/d during 6 years then zinc acetate 150 mg/d	D‐Penicillamine 900 mg/d during thirteen years, then Trientine 2HCL 600 mg/d + zinc sulfate 1200 mg/d