Drug‐related |
Excessive zinc ingestion (from dental paste, excessive oral supplementation or in Wilson's disease treatment) or iron supplements |
Decreased/inadequate intake |
Anorexic patients, malnutrition, Kwashiorkor, vegetarian, parenteral or enteral nutrition without adequate copper supplements |
Increase copper loss or inadequate absorption |
Inflammatory bowel disease (Crohn's disease, ulcerative colitis), celiac disease, bypass surgery, gastrectomy, prolonged diarrhea, protein‐losing enteropathy, tropical and non‐tropical spure |
Increase demand |
Pregnant women, lactating women, premature infants, children |
Hereditary |
Menkes disease |