TABLE 2.
Multivariate analysis of predictors selected by LASSO regression procedure in the development cohort
| Variable | HR | 95% CI | P‐value |
|---|---|---|---|
| Age at onset | 1.75 | 1.33–2.31 | 0.0001 |
| MSA subtype (MSA‐C) | 0.91 | 0.51–1.65 | 0.759 |
| Gender (female) | 1.02 | 0.67–1.55 | 0.935 |
| Early falls ≤3 y (absent) | 0.409 | 0.26–0.64 | 0.0001 |
| Catheterization ≤3 y (present) | 2.25 | 1.35–3.75 | 0.002 |
| Dopa response (absent) | 1.66 | 1.03–2.67 | 0.037 |
| Early OH (present) | 2.137 | 1.33–3.44 | 0.002 |
| Early urogenital failure (present) | 2.11 | 1.38–3.23 | 0.001 |
| Parkinsonism at onset (absent) | 1.03 | 0.62–1.74 | 0.898 |
Abbreviations: LASSO, least absolute shrinkage and selection operator; HR, hazard ratio; CI, confidence interval; MSA‐C, multiple system atrophy (cerebellar subtype); y, years; OH, orthostatic hypotension.