Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Aug 28;11(9):2401. doi: 10.3390/biomedicines11092401

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The relationship between tumor cells and CAAs in CRC tumor microenvironment. Adipocytes disposed at the tumor invasion front undergo lipolysis and transform into CAAs. CAAs support tumor growth and metastasis through a metabolic remodeling of cancer cells, local immune response modulation, tumor angiogenesis, and tumor extracellular matrix remodeling. Their activity is associated with resistance to therapy. Additionally, CAAs are cells that may be used to deliver therapeutic drugs into CRC TME. CAAs—cancer-associated adipocytes; CRC—colorectal cancer; TME—tumor microenvironment.