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. 2023 Aug 28;12(9):1681. doi: 10.3390/antiox12091681

Figure 4.

Figure 4

Metformin inhibits high glucose−induced YAP activation and improves insulin sensitivity in mouse aortas. (A–D) Representative immunoblots (A) and quantification of YAP phosphorylation (B), Akt phosphorylation (C), and eNOS phosphorylation (D) in isolated mouse aortas treated with 30 mM glucose (HG), 10 mM metformin (Met), and 100 nM insulin. (E) Representative traces. Phe: phenylephrine. (F) EDRs in mouse mesenteric arteries treated with high glucose, insulin, and metformin. M: different concentrations of Insulin (mol/L). n = 5–6. Data are means ± SD. * p < 0.05, ** p < 0.01.