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. 2023 Sep 12;12(9):1229. doi: 10.3390/biology12091229

Figure 5.

Figure 5

AKT-1005 dose-dependently reduced (a) sFLT-1 protein and (b) sEng expression (anti-angiogenic response) and increased (c) VEGF (pro-angiogenic response) in human villous explant culture during hypoxic exposure. Normalized sFLT-1/sEng/VEGF data according to different treatment groups). Abbreviations: N = normoxia; H = hypoxia; MT = MitoTEMPO. Figure (a): n = 3 per group, Shapiro-Wilk normality test. Unpaired T-tests. mean ± SEM. Figure (b,c): n = 4 per group, Mann-Whithey-U test, median [IQR]. Mean ± SEM. ****: p < 0.0001; ***: p < 0.001; **: p < 0.01; *: p < 0.05.